PEPTIDES
What are Peptides?
Peptides are the small chains of amino acids held together by peptide bonds and they are the building blocks of proteins. Peptides bind to receptors of cells and send signals that control the function of other cells and molecules. These signals can lead to increased weight loss, muscle growth, pain relief, injury recover, increased energy, improved sexual function, increased digestive health, improved neurological function, better skin quality, and countless other body functions. Peptide therapy can be thought of as the use of a specific peptide or peptides to treat a specific condition. Because peptides are naturally occurring in our bodies and very specific to the receptors they bind to, they are exceptionally safe and well-tolerated.
What is the New Era Peptide Therapy Program difference?
Through personal experience, clinical results, extensive training, and discussions with many of the leading peptide compound pharmacists and practitioners, New Era Wellness Center has discovered that certain peptides properties are amplified, and more effective results are seen when they combined and administered together.
Most peptide protocols are designed to be taken 5 days on 2 off. This allows the protocols to remain effective over time, as peptides are still susceptible to being less effective if the receptors they bind to are constantly being stimulated. Most of the peptide therapy programs are to be injected subcutaneously, but certain programs may include a topical or oral preparation
Our Peptide Approaches
BPC-157: Build & Recover
STRESS IN GASTROINTESTINAL TRACT AND STABLE GASTRIC PENTADECAPEPTIDE BPC 157
Finally, do we have a Solution? BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice.
Research has shown BPC-157 to have considerable biological healing properties. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendons, muscles, nervous system and superior healing of damaged ligaments. This peptide can be very useful to athletes or just the average person who has daily aches, pains or injury. Overuse of our body can cause muscle, tendon and ligament issues that affect our everyday life. The addition of BPC-157 can help heal those everyday aches and pains.
Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues.
BENEFITS OF BPC 157
* Accelerated wound healing (muscle, ligament, tendon, nerve)
* Anti-inflammatory
* Has been shown to decrease pain in damaged areas
* BPC 157 increases growth hormone receptors
* Promotes the outgrowth of tendon fibroblasts, cell survival under stress, and the migration of tendon fibroblasts
* Improves digestive function
* May improve blood pressure and NO production
* Protects and heals inflamed intestinal epithelium (leaky gut)
* It has also been shown to help in Inflammatory bowel disease
* Protects liver from toxic insults (alcohol, antibiotics, etc) and promotes healing
ADVANCED BENEFITS OF BPC-157:
* In tendons, BPC-157 increases fibroblast growth via phosphorylation levels of both FAK and paxillin (dose dependently)
* In collagen repair, BPC-157 stimulates EGR-1 which induces cytokine and growth factor generation and early extracellular matrix (collagen) formation
* EGR-1 also increases its co-repressors such as nerve growth factor 1-A binding protein-2 (NAB2)
* BPC-157 can increase decrease B4 (LTB4), thromboxane B2 (TXB2), and myeloperoxidase (MPO) in the serum and inflamed tissues and increase macrophages activity
Burn: Weight Loss & Fat Loss
AOD 9604 is a modified form of Growth Hormone, which is a 191 amino acid peptide. The last 15 amino acids (176-191) of the Growth Hormone polypeptide have been reproduced as a specific peptide and is called GH Frag 176-191 or AOD 9604.
This peptide is used for burning fat and medically assisted weight loss, and it has other benefits as well.
Gland Stimulated: Pituitary Gland
BENEFITS OF AOD 9604
While it's best known as a fat-burning peptide, there are plenty of other benefits to using AOD-9604. Here are some to note:
* Reduces body fat
* Triggers fat release from obese fat cells predominantly more than lean ones
* Mimics the way natural growth hormone regulates fat metabolism
* No adverse effects on blood sugar or growth
* Stimulates lipolysis
* Inhibits lipogenesis (the transformation of non-fatty foods into body fat)
* Favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157
HOW IT WORKS
AOD-9604, also known as Tyr-hGH Frag 176-191, has been proven to have a strong fat-burning capacity without creating a desire to overeat. It doesn't affect blood sugar or tissue growth. (Heffernan 2001 Heffernan 2001, Ng 2000).
AOD-9604 activates degradation and fat burning (oxidation) by a method that doesn't use the hGH receptor; it has its own mechanism of action independent of hGH. Laboratory studies on rodents, pigs, dogs & humans have identified the AOD-9604 mechanism which triggers fat release from the obese fat cells predominantly and works to reduce the accumulation of new fat in fat cells as well as increase fat burning. What is extraordinary about the AOD-9604 is its ability to reduce abdominal fat stores.
The second most potent fat loss peptide CJC since it leads to an increase in overall GH levels in the body (the opposite of what happens typically as individuals age).
This explains one of the reasons people have tended to gain fat as they get older. If your only goal is fat loss, it's usually best to avoid using products GHRP (GHRP-6, GHRP-2 or GHRH’s) because they may give you the side effects of increased hunger and raised cortisol. AOD-9604 does not increase hunger or raise cortisol.
AOD 9604 RESEARCH
AOD-9604 (Advanced Obesity Drug) was originally developed by Professor Frank Ng at Monash University in Australia in the 1990s, with the intent of finding an anti-obesity drug that had the fat-burning effects of human growth hormone (HGH) without the muscle-building effect.
Other recent findings have shown, in addition to its fat loss properties, AOD 9604 processes many other regenerative properties associated with growth hormone. Currently, trials are underway to show the application of AOD 9604 in osteoarthritis, hypercholesterolemia, and bone and cartilage repair.
Results of the oral glucose tolerance test demonstrated that, in contrast with hGH, AOD 9604 has no negative effect on carbohydrate metabolism. There were no anti-AOD 9604 antibodies detected in any of the patients selected for antibody assay. In none of the studies did a withdrawal or serious adverse event occur related to intake of AOD 9604.
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Conclusion
AOD 9604 is one of the best peptides for weight loss. It also has additional benefits that can help with fat reduction, better metabolism, and more.
AOD 9604 displayed a very good safety and tolerability profile indistinguishable from the placebo. AOD 9604 did not result in any of the adverse effects associated with full-length hGH treatment. AOD 9604 has an excellent safety profile, recently obtaining Human GRAS status in the USA.
MEND: Injury Recovery and Pain Relief
Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin beta-4, is an actin, a cell building protein.
One of the main mechanisms of action of Thymosin beta-4 is its regulation of Actin. This cell-building protein is an essential component of cell structure and movement which leads to its role in tissue repair. Tβ 4 has been found to play an important role in protection, regeneration, and remodeling of injured or damaged tissues. After an injury, Tβ 4 is released by platelets and numerous other types of cells to protect the most damaged cells and tissues and to reduce inflammation and microbial growth.
Benefits of Thymosin Beta-4
Thymosin beta-4 has a range of benefits throughout the body. Some key features to note include:
* Calms muscle spasm
* Improved muscle tone
* Increased exchange of substances between cells
* Encourages tissue repair
* Stretches connective tissue
* Helps maintain flexibility
* Reduced inflammation of tissue in joints
* Encourages the growth of new blood cells in tissue
* Increased endurance and strength
* Prevents the formation of adhesions and fibrous bands in muscles, tendons, and ligaments
* Reduces the infarct size and improves heart contractile performance
* Therapeutic effect on corneal injury and dry eye syndrome
* Antifibrotic effect on the liver
* Accelerates hair growth
How Thymosin Beta-4 Works
Recent studies have revealed that the first gene to be upregulated after an injury is a Tβ4 gene. As the body begins the recovery process, Tβ4 aids in the creation of new vessels in the injured area, which carry blood, nutrients, and reparative substances to the site. Tβ4 also has anti-inflammatory properties and works to decrease the amount of inflammatory substances, called cytokines. Inflammation plays a large role in many of the symptoms associated with a number of other conditions (i.e., Lyme disease, CFS, FM, autoimmune diseases, infections, etc.), making the potential impact of Tβ4 quite extensive.
The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following a heart attack due to its cardio and neuroprotective effects.
TB500
TB-500 is a synthetic fraction of the 43 amino acid protein thymosin beta-4. The main purpose of this peptide is to promote healing. The healing effects of TB-500 have been observed in tendons, ligaments, muscles, skin, heart, and eyes. It aids in the quick healing of wounds by promoting new blood vessel and muscle fiber growth. It upregulates cell building proteins like actin. It is fast acting and goes to the site of the injury once injected and starts to work. Benefits include:
* Increases cells in healing
* Promotes angiogenesis (blood vessel formation)
* Decreases inflammation
* Improves cell migration to the cite of the injury
* Soft tissue repair - tendon, ligament, muscle sports, and athletic injuries
* Reduces scar tissue and adhesions, helps maintain flexibility
* Significant repair and regenerative properties
* Enlarged muscle growth, muscle tone, and muscular stamina
SIDE EFFECTS
Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable peptide.
Chronic Weight Management
Approximately 70% of American adults have obesity or overweight. Having obesity or overweight is a serious health issue associated with some leading causes of death, including heart disease, stroke and diabetes, and is linked to an increased risk of certain types of cancer. Losing 5% to 10% of body weight through diet and exercise has been associated with a reduced risk of cardiovascular disease in adult patients with obesity or overweight.
The U.S. Food and Drug Administration approved Wegovy (semaglutide) injection for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), for use in addition to a reduced calorie diet and increased physical activity. This under-the-skin injection is the first approved drug for chronic weight management in adults with general obesity or overweight since 2014.
The drug is indicated for chronic weight management in patients with a body mass index (BMI) of 27 kg/m2 or greater who have at least one weight-related ailment or in patients with a BMI of 30 kg/m2 or greater.
https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014
Anti-Aging & Protein Synthesis
Aging is a major risk factor for disease and death but what is the cause of aging? Despite many theories it is still unknown. What we know is that as we age our body produces fewer proteins that have a large number of important functions in our body. For example:
Peptide Importance
Proteins are vital to cell division, which is necessary for growth, reproduction and healing.
Immune Boosting
Protein is essential for the immune system to defend against foreign invaders such as bacteria and viruses.
Vital To Bodily Functions
Many proteins keep everything working right by regulating chemical reactions.
Helps Transport Nutrients
Proteins help to transport other nutrients around the body by binding to them and then releasing them when and where they are needed.
Build: Strength and Muscle Growth
This protocol is designed to improve hypertrophy, strength, and recovery from workouts
CJC-1295 & Ipamorelin
As stated in the Build Peptide program CJC-1295 and Ipamorelin work synergistically to increase the release of growth hormone from the pituitary gland. This increase in growth hormone leads to an increase in fat loss, muscle growth, and quality sleep amongst other benefits. This peptide combination is distinctive for the ability to increase growth hormone production without a subsequent increase in appetite
Burn: Weight Loss & Fat Loss
This protocol is designed to improve weight loss, lipolysis (fat loss), and body composition
AOD 9604
AOD 9604 peptide is a modified fragment of human growth hormone (GH) originally researched to treat obesity. While it did not pass phase 3 clinical trials for this effect, AOD 9604 showed the potential to assist with repairing and regenerating cartilage in arthritic patients, especially when paired with BPC-157.
MEND: Injury Recovery and Pain Relief
This protocol is designed to minimize aches, pains and minimal injuries.
Thymosin Beta-4
Thymosin is a protein naturally produced in our body by the thymus gland that stimulates the production of disease fighting T-cells. Thymosin Beta-4 is the main variant of thymosin found in our bodies and found in higher concentration where tissue has been damaged. Thymosin Beta-4 plays a crucial role in protecting, regenerating, and remodeling of injured or damaged tissues including tendons, ligaments, and muscles. Additionally, when the body sustains an injury, Thymosin Beta-4 contributes to the creation of newer, healthier blood vessels in the traumatized area. This peptide also contains anti-inflammatory properties and studies have shown it may reduce microbial growth
BPC-157
BPC-157 is a peptide chain that has been shown to accelerate the healing of many different wounds, including tendon-to-bone healing and damaged ligaments. BPC-157 has also been shown to be anti-inflammatory, decrease pain in damaged areas, and increase growth hormone receptors. This peptide may also increase the rate at which burns heal and increase blood flow to damaged tissues.
AOD 9604
AOD 9604 peptide is a modified fragment of human growth hormone (GH) originally researched to treat obesity. While it did not pass phase 3 clinical trials for this effect, AOD 9604 showed the potential to assist with repairing and regenerating cartilage in arthritic patients, especially when paired with BPC-157.
SEXUAL HEALTH/ TANNING
Melanotan II
Melanotan Non-selectively mimics the action of melanocortin peptides. These are natural hormones involved with pigmentation, energy homeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system. Much like melanotan I (afamelanotide), melanotan II stimulates the production of eumelanin, causing the skin to go darker (tanning).
During clinic trials for its use as a tanning agent, melanotan II was found to be a potent stimulator of male erections. A new drug based on melanotan II, bremelanotide, was developed to take advantage of this property. It has been noted across several studies to increase rigidity and duration of male erection, as well as male sexual desire. It has also been shown to increase female sexual desire in patients with sexual arousal disorder.